Biochemistry is a field for creative, imaginative and hard working individuals. Biochemists are curious about the chemical origins of life, the cell, the effects of organisms on the cell.we will teach biochemistry to give students a basic understanding of life processes at cellular level. We expect from our students to develop skills as a self directed learner, recognize continuing educational needs and use appropriate learning resources.
35 weeks in academic year.
4 hours lectures per week.
2 hours practical per week.
2 hour Tutorial.
Total teaching hours 350 hours.
The students of Khawaja Muhammad Safdar Medical College First year will be under the University of Health Sciences Lahore.
There are 11 modules in their first year syllabus.
1. Cell Biochemistry: is related to organization and composition of cell . Transport of substances across the cell membrane via different transport systems. Membrane receptors and different basic methods to study cell biochemistry.
2. Water, pH and Buffers: Ionization of water, weak acid and bases. pHand pHscale.Body buffers and their mechanism of action.
3. Carbohydrates: Biochemical function and classification. Structure and function of Monosaccharides, Disaccharides, Oligosaccharides and Polysaccharides. Detail of GLycosaminoglycans, proteoglycans.
4. Proteins: Biomedical importance and classification of proteins. Classification of amino acids. Dissociation and titration of amino acids. Structural organization of protein. Techniques for separation of proteins. Immunoglobulins their types, structure and biomedical significance. Plasma proteins, their functions along with clinical significance.
5. Nucleotides and Nucleic acids: Chemistry of purine and pyrimidine their types and structure. Natural and synthetic derivatives of purines and pyrimidines and their role in health and disease. Structure and functions of nucleotides.
6. Lipids and fatty acids: Classification of lipids and their biological functions. Fatty acids classification, chemical and physical properties. Role of saturated and unsaturated fatty acids in health and disease. Role of trans fatty acids in coronary artery disease. Lipid peroxidation of cell membrane.Phospholipids.Structure of cholesterol and its role in coronary artery diseases.
7. Enzymes: Classification of enzymes. Enzyme inhibitors .Enzymes and their role as markers in different diseases. Regulation of enzymatic activity. Mechanism of action.
8. Hemoglobin: Structure, Oxygen binding capacity.Degradation of heme. Hyperbilirubinemia and hemoglobinopathies.
9. Vitamins and Minerals: General features of vitamins as essential nutrients. classification, sources and recommended daily allowances. mechanism of action and disorders. Minerals sodium, potassium, chloride calcium, sulfur and trace elements their sources, absorption, transport, storage and functions.
10. Nutrition: Energy metabolism, caloric values, Balanced diet, Fats, proteins and carbohydrates in nutrition.
11. Extracellular matrix:
Collagen: Types, structure, synthesis and degradation.
Elastin: Structure, synthesis and disorders
Glycosaminolycans: structure, classification, function, distribution and diseases.
Introduction of laboratory facilities.
Preparation of solutions.
Demonstration of buffer system
Qualitative analysis of carbohydrates, proteins and fats.
Collection and storage of urine samples.
Harper s Illustrated Biochemistry by Murray RK
Lippincott s Illustrated Reviews
Marks basic medical biochemistry.